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Int J Biol Sci ; 11 How to cite this article: However, no studies have investigated any causality between androgen, androgen receptor AR expression, and adenosine monophosphate activated protein kinase AMPK activation in the endometrium under physiological and pathological conditions. In addition to its negative effects on endocrine activity and metabolism, PCOS has adverse impacts on female reproduction [ 1 , 3 ]. For example, women with PCOS generally have chronic anovulation, and their endometria tend to remain in a proliferative state due to the lack of counterbalance by progesterone [ 4 ]. It is generally believed that the failure of reproductive success in PCOS patients could be in part due to endometrial dysfunction [ 7 , 8 ]. The human endometrium plays an essential role in menstruation, implantation, pregnancy, and endometrial repair [ 7 ] through alterations of epithelial and stromal cell proliferation, differentiation, secretion, and apoptosis [ 9 ]. The modulation of different protein expression and signaling pathways has been shown to influence endometrial function [ 7 , 10 ]. In addition to estrogen and progesterone [ 10 ], androgen is also essential for female reproduction through the activation of androgen receptor AR , which belongs to a member of the steroid receptor superfamily and regulates transcription of target genes [ 11 ]. AR undergoes cyclical changes in expression and has different endometrial cell localization and regulation patterns in women during the menstrual cycle [ 10 , 11 ].

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Received Aug 1; Accepted Jan This article has been cited by other articles in PMC. Abstract At the crossroads between Africa and Eurasia, Arabia is necessarily a melting pot, its peoples enriched by successive gene flow over the generations. Estimating the timing and impact of these multiple migrations are important steps in reconstructing the key demographic events in the human history.

An mtDNA-based founder analysis, corroborated by detailed analysis of the whole-mtDNA genome, affords an alternative means by which to identify, date and quantify multiple migration events at greater time depths, across the full range of modern human history, albeit for the maternal line of descent only. In Arabia, this approach enables us to infer several major pulses of dispersal between the Near East and Arabia, most likely via the Gulf corridor.

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Copyright remains with the author s or their institution s. Permission for reuse free in most cases can be obtained from RightsLink. Published on the web 13 April Canadian Journal of Earth Sciences, , 53 9: One porphyry intrusion yielded a U—Pb age of Mineralization occurs in three stages: Re—Os dating of molybdenite yielded ages of Stage 1 vein fluids were predominantly of magmatic origin:

Genetic Stratigraphy of Key Demographic Events in Arabia

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Wikimedia Commons has media related to Imperial units of measure in use in the United Kingdom. Public copies of the standard yard and its subdivisions at Greenwich Observatory. The British Weights and Measures Act of repealed all existing British weights and measures legislation, some dating back to the s, and redefined existing units of measure. In particular, a new standard yard and troy pound were manufactured as the standards for length and weight respectively.

The act also set up an inspectorate for weights and measures. Following a report published in by a commission new standard yard and pound were manufactured using the best available secondary sources.

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History[ edit ] One of the challenges in studying abiogenesis is that the system of reproduction and metabolism utilized by all extant life involves three distinct types of interdependent macromolecules DNA , RNA , and protein. This suggests that life could not have arisen in its current form, which has led researchers to hypothesize mechanisms whereby the current system might have arisen from a simpler precursor system. He proposed that these nucleotide cofactors represent “fossils of nucleic acid enzymes”.

Opinions differ, however, as to whether RNA constituted the first autonomous self-replicating system or was a derivative of a still-earlier system. On the other hand, the discovery in that activated pyrimidine ribonucleotides can be synthesized under plausible prebiotic conditions [17] suggests that it is premature to dismiss the RNA-first scenarios. Ribozymes play vital roles, such as that of the ribosome , an RNA-protein complex responsible for protein synthesis.

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For improvement of ventilatory function in stable, non-acute members with SCI when all of the following criteria are met: Member has high quadriplegia at or above C-3; and There are viable phrenic nerves; and Member’s diaphragm and lung function are adequate; and Diaphragmatic pacing will allow the individual to breathe without the assistance of a mechanical ventilator for at least four continuous hours a day.

For the treatment of central alveolar hypoventilation when all of the following criteria are met: Age of 18 years and older; and Have intact phrenic nerve function; and Have diaphragm movement with stimulation. Aetna considers electrical stimulation of the sacral anterior roots by means of an implanted stimulator, the Vocare Bladder System in conjunction with a posterior rhizotomy medically necessary for members who have clinically complete spinal cord lesions American Spinal Injury Association Classification with intact parasympathetic innervation of the bladder and who are skeletally mature and neurologically stable, to provide urination on demand and to reduce post-void residual volumes of urine.

The following selection criteria must be met: Aetna considers electrical stimulation of the sacral anterior roots in conjunction with posterior rhizotomy Vocare Blader System experimental and investigational for all other indications because its effectiveness for indications other than the ones listed above has not been established. Aetna considers sacral nerve stimulation experimental and investigational for the treatment of chronic constipation because its effectiveness for this indication has not been established.

The Vocare Bladder System is patient-activated and is designed to elicit functional contraction of the innervated muscles. Implantation of the Vocare device is frequently performed in conjunction with a dorsal rhizotomy.

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